What is the treatment for Obstructive Sleep Apnea? Most commonly, positive airway pressure (PAP) therapy is the treatment of choice for OSA. It is noninvasive and can alleviate the symptoms of OSA when used as prescribed. Less commonly, surgery or oral appliances are used, which may be effective in certain cases. Any treatment plan should include weight loss if needed, exercise, and avoidance of alcohol, sedatives, and hypnotics.